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Huai L. Feng

 

 

 doctorf88@gmail.com

 

Education

2006                      MBA, Health Service Management and Hospital Administration, Frank G.ZarbSchoolof Business,

                                Hofstra University, NY

1992                      Ph.D.  Embryology, Department of Bioengineering, Northeast Agriculture University, Harbin, China

1987                      M.S.  Embryology, Department of Histology and Embryology, Jilin University, Changchun, China

1984                      B.A.  Jilin University, Changchun, China

 

Licensure and Certification

1997-                     American board certification of High Complexity Laboratory Director (HCLD) and Embryology

Laboratory Director (ELD),Andrology Laboratory Director (ALD) , American Board of Bioanalysis, USA.

1997-                     American board certification of Technical Supervisor, American Board of Bioanalysis

1997-                     American board certification of Embryology, American Board of Bioanalysis.

1997-                     American board certification of Andrology, American Board of Bioanalysis.

2012-                     American board certification of clinical consultant, American Board of Bioanalysis.

2000-                     The Certificate of Qualification (CQP9496) as a Clinical Laboratory Director in Andrology and Endocrinolgy specialty, New York State Department of Health, NY.

2000-                     Tissue Bank Director for Oocytes/Embryos and Male Reproductive Tissues donors and Client- Depositors, New York State Department of Health, NY.

2001-                     The Certified Inspector for Laboratory Accreditation Program byCollegeofAmericanPathologists, IL,USA.

2007-                     Clinical Laboratory Technologist, Registration Certificate, The University of the State of New York, Education Department, Office of the professions. (Number#: 6087858)

2011-                 Clinical Laboratory Improvement Amendments (CLIA) , Laboratory Director

 

Academic Appointments

1987-1989            Assistant Professor (Lecturer), Jilin University, Changchun, China

1992-1993           Associate Professor and Director, Laboratory of Embryo Technology, Jilin University, Changchun, China

1993-1995            Fellow, Center for Reproductive Science, Northwestern University, Chicago, IL.

1995-1998         Assistant Professor, Departments of Urology and Ob/Gyn, University of Iowa Hospitals and Clinics, Iowa City, IA.

1998-2009            Associate Professor, Department of Ob/Gyn, NYU School of Medicine, Manhasset, NY, USA

2009-2011           Associate Professor, Department of Ob/Gyn, Hofstra University School of Medicine, NY, USA.

2011-                     Clinical Professor, Weill Cornell Medical College, Cornell University, NY, USA.

2011-                    Clinical Professor, Department of Obstetrics and Gynecology, the University of Texas Southwestern       

                            Medical Center at Dallas, TX, USA.

 

 

Professional Appointments

1998-1999            Laboratory Director, Fertility (IVF and Andrology) / Reproductive Endocrinology Laboratories, Department of Ob/Gyn, the Brooklyn Hospital Center, NYU School of Medicine, Brooklyn, NY, USA.

1999-2011            Director of Infertility and Embryology Laboratories, Department of Ob/Gyn, North Shore University

Hospital, NYUSchoolofMedicine,Manhasset,NY

1999-2011            Assistant directors, North Shore University Hospital Core Laboratories, Manhasset, NY

2004 -2006           Laboratory Director (off-site), Downtown Fertility of New York, New York, NY,USA.

2002-2011            Laboratory Director (off-site), Gold Coast IVF, Syosset, NY, USA

2000-2009            Laboratory Director (off-site), Staten Island Fertility Center, Staten Island, NY, USA

2008-                     Laboratory Director, New York Fertility Center, New York Hospital Queens, Weill Cornell Medical College, Cornell University, NY, USA

2011-                    Scientific Director, New York City IVF Center, New York, NY

2011-                   Director, IVF Laboratory, Department of Obstetrics and Gynecology, the University of Texas     Southwestern Medical Center at Dallas.

 

Awards and Honors

1985-1993            Over thirty scientific and technological awards from State Nature Sciences and

  Technology Committee and State Medical Ministry, China

1992                      “Outstanding young scientist” , National Sciences Association, China

1994                      Fellowship awards, Mellon Foundation,USA

1998                        Young Scientific awards from Society for Male Reproduction and Urology, USA.

2005                     The Leading Scientists of the World 2005, IBC,Cambridge,UK.

2006                      Awarded the outstanding inspectors for 2006 from College of American Pathologists (CAP).

 

Honor Academic Titles

2002                      Honor Professor, Department of Ob/Gyn, Shandong Province Hospital, Jinan, China

2004                      Guest Professor, Shandong University, Jinan, China

2005                      Guest Professor, Inner Mongolia University, Huhhot.

2006                      Visiting Professor, the ChineseUniversityofHong Kong, HK

2007                      Guest Professor, Anhui Medical University, Anhui, China.

2008                      Visiting Professor and Guest Professor, Peking University Third Hospital, Beijing, China

2009                      Adjunct Professor, Jilin University, Changchun, China

  2011                     Guest Professor, Zheng Zhou University First and Third Hospital, Zheng Zhou, China

  2012                 Distinguished Professor, Guangzhou Traditional Medicine University, Guangzhou, China

  2012                     Guest Professor, Xinjiang Medical University, China

 

Research Interest:

·         Gametogenesis, oocyte maturation and age, sperm function, and fertilization biology

·          Early embryo development and regulation

·         Stem cells

·         Genetic, Epigenetic and Imprinting

·         ART and its safety

 

Bibliography:

 

A.  Selected Book and/or Chapters Publications:

Li, Yuan, Feng, HL, Cheng, Zijiang, Assisted Reproductive Technology in Human, Beijing Scientific Publishing House,

      2008

Feng, H.L. (1994) Embryo Technology in Mammalian, The Serial Books Written by Young Scientists, Jilin Science and

     Technology Publishing House, Changchun, China, pp1-320.

 

B.  Selected Paper Publications or in Press (From more than 200):

   Lu C, Zhang Y, Zheng X, Song X, Ruiyang, Jieyan, Qiao J,  Feng HL. (2018) Current perspectives on in vitro maturation 

       and its effects on oocyte genetic and epigenetic profiles.  Sci China Life Sci. doi: 10.1007/s11427-017-9280-4.

  Xu B, Feng HL. Ovulation, fertilization and preimplantation embryonic development in raccoon dogs (Nyctereutes

        procyonoides). Anim Reprod Sci. 2017 Jan;176:78-84.

  Deekshya Shrestha, Xiaolin La, Feng HL. (2015) Comparison of different stimulation protocols used in in  

      vitro fertilization: a review Ann Transl Med. 3(10):137

  Lu CL, Wang TR, Yan LY, Feng HL, Qiao J. (2014) Gonadotropin-Mediated Dynamic Alterations During Bovine Oocyte   

      Maturation In Vitro. Biology of Reproduction, 91(2):44, 1–9.

  Zhang L, Tang J, Haines C, Feng HL,  Han YB. (2014) C  kit expression profile and regulatory factors during 

      spermatogonial stem cell differentiation. EMC Dev Biol, 13:38-41.

  Le W, Huang SS, Gui YP, Luo HR, Wu DL, Feng HL, Zhang JF (2014). Assessment of numerical chromosomal

      abnormalities of the sperms before and after radiotherapy in seminoma patient.  Int J Clin Exp Med. 7(3):703-708.

 Qiao J, Feng HL 2014. Assisted reproductive technology in China: compliance and non-compliance.

     Transl Pediatr 3(2):91-97.

  Wang XM, Zhang Z, Tsai T, Feng HL. (2014) Impact of Gonadotrophins on Oocyte Maturation, Fertilization and 

      Developmental Competence in vitro: Animal Model. Reprod Fertil Dev.26(5):752-7

  Qiao J, Wang ZB, Feng HL, Miao YL, Wang Q, Yu Y, Wei YC, Yan J, Wang WH, Shen W, Sun SC, Schatten H,   

       Sun QY. 2013. The root of reduced fertility in aged women and possible therapentic options: Current status and future     

       perspects, Mol Aspects Med. 38 (2014) 54–85.    

  Wang XM, Zhang Z, Tsai T, Feng HL. (2013) Impact of Gonadotrophins on Oocyte Maturation, Fertilization and 

     Developmental Competence in vitro: Animal Model. Reprod Fertil Dev. 2013 Jun 3. [Epub ahead of print]

Liu N, Ma Y, Li R, Jin H, Li M, Huang X, Feng HL, Qiao J. (2012) Comparison of follicular fluid amphiregulin and EGF concentrations in patients undergoing IVF with different stimulation protocols. Endocrine. 2012 Dec;42(3):708-16.

Wang XM, Feng, H. L. (2012) How to Achieve the best ART pregnancy rate via sperm selection. J. Int. Reprod Health. 31:373-377

Hu WH, Mechesi D, Qiao J, Feng HL. (2012) Effect of slow freeze verus vitrification on the oocyte: An animal  model. Fert. Steril. 98:752–60.

Marchesi D., Feng, H.L., Qiao.J. (2012) Embryo Manipulation and Imprinting, Seminars in Reprod Medicine,

     30:323-334.

Liu S, Feng, HL.  (2011) Effect of gonadotropins on dynamic events and global DNA methylation during in vitro maturation

     of oocytes: an animal model, Fertil Steril. 95(4):1503-1506.e3. Epub 2010 Nov 10.

Qiao J., Feng, H.L. (2011)Extra- and Intra-ovarian Factors in Polycystic Ovary Syndrome (PCOS): Impact on Oocyte Maturation and Embryo Developmental Competence. Human Reproduction Update, 17 (1): 17-33.

Liu S, Li Y, Feng HL, Yan JH, Chen ZJ (2010) Dynamic Modulation of Cytoskeleton During In Vitro Maturation in Human

Oocytes. Am J Obstet Gynecol. 203:151.e1-7.

Marchesi D, Biederman H, Hershlag A, Feng HL (2010) Effect of semen processing on sperm DNA integrity: Comparison of two techniques using a novel Toluidine Blue assay. European Journal of Obstetrics & Gynecology

    And Reproductive Biology 151 (2010) 176–180

Sha W, Xu BZ. Li M, Liu D, Feng HL*, Sun QY.  (2010) Impact of Gonadotrophins on Oocyte Maturation in vitro: An Animal Model. Fertility and Sterility, 93:1650-61.

Feng H L. (2009) Spermatozoa defect and Fertilization Failure. J Reprod. Med. 18(3):187-189.

Han YB, Feng HL, Sandlow, J, Haines C. (2009) Comparing expression of progesterone and estrogen receptors in testicular tissue from men with obstructive and non-obstructive azoospermia, J. Andrology., 30:127-133.

Feng HL. Han YB, Sparks AET, Sandlow JI (2008) Characterization of Human Sperm Antigens Reacting with

Antisperm Antibodies from an Infertile Female Patient’s Serum. J Androl. 2008 Mar 20;29:440–448

Feng HL, Hershlag A, Scholl GM, Cohen M. (2009) A retroprospective study comparing four different assisted hatching techniques. Fertility and Sterility, 91:1323-5.

Marchesi DE, Feng HL (2007) Current assessment of sperm DNA integrity, Archives of Andrology,

53:239-247.

Marchesi D.E and Feng , HL. (2007) Sperm DNA Integrity from Sperm to Egg, Journal of Andrology, 28(4):481-489. Feng, H.L., Han, Y.B., Hershlag, A, Zheng, LJ. (2007) The Impact of Ca2+  Flux Inhibitors on Acrosome Reaction of

Hamster Spermatozoa, J. Andrology, 28(4):561-4.

Feng, H.L., Hershlag, A., Han, Y.B., Zheng, L.J. (2006) Localizations of intracellular calcium and Ca2+-ATPase in hamster spermatogenic cells and spermatozoa, Microscope Res. Tech. 69:618-623.

Feng, HL. Han, Y.B., Hershalg, A., Yang, H. (2006) New Hope for Infertility Therapy: Fabricating Gametes from

      StemCells, Arcives of Andrology., 52:233-8.

Chen, Z.J., Yuan, J.H., Feng, H.L. (2005) Source of the extra pronucleus after intracytoplasmic sperm injection?

Fertility and Sterility,  84(5):1553-1554.

Herhlag A., Feng, H.L. (2005) Impact of medium pH on murine embryogeneis,  Fertility 4:21-22.

Li, Y., Feng, H.L., Cao, Y.J., Ma, S.Y., Li, M., Hu, J.M., Chen, Z.J. (2006) Confocal Microscopy Analysis of the

Spindle and Chromosome Configurations of Human Oocytes Matured in vitro. Fertility and Sterility, 85(4):827-

32.

Hershlag, A., Feng, H.L. (2005) The Effect of Pre-Freeze Assisted Hatching on Post-Thaw survival of mouse embryos, Fertility and Sterility,  84(6):1752-1754.

Chen, Z. J., Yan, J.H., Feng, H.L. (2005) Aneuploid Analysis of tripronuclear zygotes derived from in-vitro

fertilization and intracytoplasmic sperm injection in human, Fertility and Sterility, 83:1845-8.

Feng, H.L., Sandlow, J.I., Zheng, L.J. (2004) The c-kit receptor and its possible function in human spermatozoa,

 Molecular Reproduction and Development, 70:103-110.

Chen, Z. J., Li, M.,  Li, Y., Feng, H.L. (2004) Effects of Sucrose Concentration on the Developmental Potential of

Human Frozen-Thawed Oocytes at Different Maturity Stages, Human Reproduction, 19(10 ):2345–2349.

Xu, H.P., H.L. Feng (2004) Localization and expression of the TSP50 protein in human and rodent testis, Urology,

64 (4):826-832

Feng, H.L., Hershlag, A. (2003) Fertilization abnormalities following human in-vitro fertilization and

intracytoplasmic sperm injection,  Microsc Res Tech., 61(4):358-61.

Hershlag, A., Feng, H. L. (2003) Betadine (povidone-iodine) is toxic to murine embryogeneis , Fertility and Sterility, 79(5):1249-1250.

Feng, H. L. (2003) Molecular Biology of Male Infertility, Archives of Andrology, 49:19-27.

Hershlag, A., Pain, T, Kvapil, G., Feng, H.L. (2002) In vitro fertilization-intracytoplasmic sperm injection split: an insemination methos to prevent fertilization failure, Fertil. Steril. 77:229-32.

Feng, H.L., Sandlow, JI.,Sparks, AET. (2001) Decreased expression of the heat shock protein hsp70-2 is associated

with the pathogenesis of male infertility, Fert. Steril. 76:1136-1139.

Feng, H.L., Sandlow, JI.,Sparks, AET., Sandra, A., Zheng, LJ. (1999) Decreased expression of the c-kit  receptor

is associated with increased apoptosis in subfertile human testes, Fertil. Steril. 71:85-89.

Feng, H.L., Sandlow, JI., Sandra, A.,Sparks, AET. (1999) Development of Immunocontraceptive vaccine:

current status, J. Reprod. Medicine. 44:759-765.

Feng, H.L., Sandlow, J.I. and Sandra, A. (1998) Presence of c-kit receptor and its possible signaling

pathway in mouse sperm, Mol. Reprod. Dev. 49:317-326.

Sandlow, J.I., Feng, H.L. Zheng, L.J.and Sandra, A. (1999) Migration and localization of the c-kit receptor protein in

spermatogenetic cells and spermatozoa of the mouse, J. Urology, 161:1676-80.

Sandlow, J.I., Feng, H.L. and Sandra, A. (1997) Localization and expression of the c- kit receptor protein

in human and rodent testis and spermatozoa, Urology., 49:494-500.

Feng, H.L., Sandlow, J.I. and Sandra, A (1997) Expression and function of the c-kit proto-oncogene

protein in mouse sperm, Biol. Reprod. 57: 194-203.

Feng, H.L., Wen, X.H., Theodore, A., and Presser, S.C. (1996) Effect of different coculture systems in

early human embryo development, Human Reproduction., 11:1525-1528.

Sandlow, J.I., Feng, H.L. and Sandra, A. (1996) Expression of c-kit and its ligand, stem cell factor, in

normal and subfertile human testicular tissue, J. Andrology,  17:403-408.

Sun Q.Y.  Yang Q.Z. Liu G.Y. Feng H.L (1995) Cryopreservation of bovine oocytes matured in vitro, Theriogenology, 43:329-330.

Feng, H.L., Yang, Q.Z., Sun, Q.Y., Qin, P.C. and Liu, J.M. (1994) Development of early bovine embryos in different culture systems, Vet. Rec., 135:304-306.

Feng, H.L., Liu, J.M., Wen, X.H., Wang, J., Sun, Q.Y. and Qin. P.C. (1994) Follicular oocyte maturation

and sperm penetration in vitro in the silver fox (vulpes vulpes),  Anim. Reprod. Sci., 36:163-170.

Feng, H.L. and Sun, Q.Y. (1995) Cryopreservation of bovine oocytes matured in vitro, J. Anim.

Sci. Vet. Med., 26:481-486.

Feng, H.L. and Sun, Q.Y. (1994) Development competence of bovine follicular oocytes after cryopreservation,  J. Vet. Sci., 

    14:341-345.