固定研究人员
闫丽盈

闫丽盈
副研究员

研究方向
卵母细胞成熟、早期胚胎发育的分子机制以及胚胎干细胞建系及其全能性维持的分子机制。

受教育经历
2003/09-2006/07,中国科学院动物研究所,生殖生物学国家重点实验室,博士;
2000/09-2003/07,北京大学医学部,公共卫生学院,硕士;
1995/09-2000/07,同济医科大学,公共卫生学院,本科。

工作经历
2010/08-至今,北京大学第三医院生殖医学中心,副研究员;
2006/08-2010/07,北京大学第三医院生殖医学中心,助理研究员。

主持或参加科研项目及人才基金项目情况
1.北医三院-中科院联合项目,卵母细胞冷冻保存的深低温生物学机制探讨,2013/08-2014/07,40万,在研,主持;
2.技部重大科学计划(973),2011CB944503,卵巢冷冻保存:低温生物学技术优化与生物功能维持、2011/01-2015/12、200万、课题骨干、子课题负责人;
3.国家自然科学基金青年基金,81000275、PTEN抑制剂对卵泡体外成熟的影响、2011/01-2013/12、20万元、已结题,主持;
4.教育部博士点新教师基金,20090001120113、卵母细胞玻璃化冷冻对胚胎及后代的影响、2010/01-2012/12、3.6万元、已结题、主持。

发表文章情况:
1.Lu Wen#, Xianlong Li#, Liying Yan#, Yuexi Tan#, Rong Li, Yangyu Zhao, Yan Wang, Jingcheng Xie, Yan Zhang, Chunxiao Song, Miao Yu, Xiaomeng Liu, Ping Zhu, Xiaoyu Li, Yu Hou, Hongshan Guo, Xinglong Wu, Chuan He*, Ruiqiang Li*, Fuchou Tang*, Jie Qiao*. Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain. Accepted by Genome Biology,2014(#: 并列第一作者).
2.Yu Hou#, Wei Fan#, Liying Yan#, Rong Li, Ying Lian, Jin Huang, Jinsen Li, Liya Xu, Fuchou Tang*, X. Sunney Xie,* and Jie Qiao*.Genome Analyses of Single Human Oocytes. Cell. 19,155, 1492-1506. 2013(#: 并列第一作者)。
3.Lu S, Peng H, Zhang H, Zhang L, Cao Q, Li R, Zhang Y*, Yan L*, Duan E, Qiao J. Excessive intrauterine fluid cause aberrant implantation and pregnancy outcome in mice. PLoS One. 23;8(10):e78446,2013 (*: 并列通讯作者).
4.Liying Yan#, Mingyu Yang#, Hongshan Guo, Lu Yang, Jun Wu, Rong Li, Ping Liu, Ying Lian, Xiaoying Zheng, Jie Yan, Jin Huang, Ming Li, Xinglong Wu, Lu Wen, Kaiqin Lao, Ruiqiang Li, Jie Qiao, Fuchou Tang. Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nat Struct Mol Biol.  20(9):1131-9, 2013(#: 并列第一作者).
5.Wang TR, Yan LY, Yan J, Lu CL, Xia X, Yin TL, Zhu XH, Gao JM, Ding T, Hu WH, Guo HY, Li R, Qiao J. Basic fibroblast growth factor promotes the development of human ovarian early follicles during growth in vitro. Hum Reprod. 29(3):568-76. 2014.
6.Lin SL, Tu BB, Du XG, Yan LY, Qiao J. Lower expression of ER-α36 is associated with the development of endometrial hyperplasia in PCOS patients. Histol Histopathol. 28(11):1491-8, 2013.
7.Lu S, Zong C, Fan W, Yang M, Li J, Chapman AR, Zhu P, Hu X, Xu L, Yan L, Bai F, Qiao J, Tang Fuchou, Li R, Xie XS. Probing meiotic recombination and aneuploidy of single sperm cells by whole-genome sequencing. Science; 338: 1627-1630. 2012.
8.Yan J#, Yang Y#, Liying Y#, Zichuan L, Ping L, Huailiang F, Qi Z, Jie Q. In vitro maturation of cumulus-partially enclosed immature human oocytes by priming with gonadotropin. Fertil Steril. 96(3):629-634, 2011(#: 并列第一作者).
9.Tu BB#, Lin SL#, Yan LY#, Wang ZY, Sun QY, Qiao J. ER-α36, a novel variant of estrogen receptor α, is involved in EGFR-related carcinogenesis in endometrial cancer. Am J Obstet Gynecol. 205(3):227.e1-6, 2011.(#: 并列第一作者).
10.Yan LY, Yan J, Qiao J, Zhao PL, Liu P. Effects of oocyte vitrification on histone modifications. Reprod Fertil Dev.22(6):920-5, 2010
11.Ma CH#, Yan LY#, Qiao J, Sha W, Li L, Chen Y, Sun QY. Effects of tumor necrosis factor-alpha on porcine oocyte meiosis progression, spindle organization, and chromosome alignment. Fertil Steril. 93(3):920-6, 2010.(#: 并列第一作者).
12.Qiao J, Chen Y, Yan LY, Yan J, Liu P, Sun QY. Changes in histone methylation during human oocyte maturation and IVF- or ICSI-derived embryo development. Fertil Steril.  15;93(5):1628-36, 2010.
13.Chen Y, Qiao J, Yan LY, Huang S, Zhao PL, Yan J. Selective impairment in glycogen synthase kinase-3 and mitogen-activated protein kinase phosphorylation: comparisons with the hyperandrogenic and the hyperinsulinemic rats. Fertil Steril.92(4):1447-55, 2009.
14.Yan LY, Qiao J, Chen Y, Huang J, Liu P, Sun QY. Application of three-dimensional fluorescence in situ hybridization to human preimplantation genetic diagnosis. Fertil Steril. 92(4):1492-5, 2009.
15.Zhu ZY, Jiang MX, Yan LY, Huang JC, Lei ZL, Jiang Y, Ouyang YC, Zhang HX, Sun  QY, Chen DY. Cytoskeletal and nuclear organization in mouse embryos derived from  nuclear transfer and ICSI: a comparison of agamogony and syngamy before and during the first cell cycle. Mol Reprod Dev, 74(5):655-63, 2007.
16.Huang JC, Yan LY, Lei ZL, Miao YL, Shi LH, Yang JW, Wang Q, Ouyang YC, Sun QY, Chen DY. Changes in histone acetylation during postovulatory aging of mouse oocyte. Biol Reprod. 77(4):666-70, 2007.
17.Yan LY, Huang JC, Zhu ZY, Lei ZL, Shi LH, Nan CL, Zhao ZJ, Ouyang YC, Song XF, Sun QY, Chen DY. NuMA distribution and microtubule configuration in rabbit oocytes and cloned embryos. Reproduction, 132(6):869-76, 2006.
18.Yan LY, Shi LH, Sheng HZ, Liu SZ, Huang JC, Zhu ZY, OuYang YC, Lei ZL, Song XF, Sun QY, Chen DY. Dynamic changes in NuMA and microtubules in monkey-rabbit nuclear transfer embryos. Front Biosci. 1;11:1892-900, 2006.
19.Liu SZ, Jiang MX, Yan LY, Jiang Y, Ouyang YC, Sun QY, Chen DY. Parthenogenetic and nuclear transfer rabbit embryo development and apoptosis after activation treatments. Mol Reprod Dev. 72(1):48-53,2005.
20.Polymorphism of methionine synthase gene in nuclear families of congenital heart disease. Zhu WL, Cheng J, Dao JJ, Zhao RB, Yan LY, Li SQ, Li Y. Biomed Environ Sci. 17(1):57-64, 2004.

获奖:
1.乔杰,黄荷凤,孙莹璞,闫丽盈,曲凡,刘平,马彩虹,徐键,李蓉,黄锦,不孕症病因及治疗方法的研究与临床应用,国家科技部,国家科学技术进步二等奖,2011年。
2.乔杰,杨艳,李蓉,黄铄,陈媛,王丽娜,王颖,刘平,马彩虹,闫丽盈,多囊卵巢综合征病因学及治疗方法的研究,北京市科委,北京市科学技术二等奖,2011年。

专利:
乔杰,闫丽盈,严杰,刘平,廉颖,一种生物材料玻璃化冷冻载体及其制备方法,2012年,中国,ZL 200810119992.4。


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