客座教授
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冯怀亮


教育经历
2006 工商管理硕士,纽约霍夫斯特拉大学,州弗兰克G.扎布商学院,健康服务和医院管理
1992 博士,胚胎学,东北农业大学生物工程系
1987 硕士,胚胎学,吉林大学
1984 学士,吉林大学

临床执照和证书
1997- 美国生物分析委员会认证的高精密临床实验室主任(HCLD)和胚胎学实验室主任(ELD),男科实验室主任(ALD)
1997- 美国生物分析委员会认证的临床技术总监
1997- 美国生物分析委员会认证的胚胎学专家
1997- 美国生物分析委员会认证的男性学专家
2012- 美国生物分析委员会认证的的临床顾问
2000- 美国纽约州认证的男科和内分泌临床实验室主任
2000- 美国纽约州认证的组织银行主任
2001- 美国病理学家协会认证的辅助生殖技术资质检查员
2007- 美国纽约州认证的临床实验室技师
2011- 美国临床实验室改进修正委员会(CLIA)认证的临床实验室主任

工作经历
1987 吉林大学,讲师
1992 吉林大学,主任,副教授
1993-1995 美国西北大学生殖科学中心,研究员
1995-1998 美国爱荷华大学医院泌尿和妇产科系,助教授(研究员)
1998- 美国纽约大学医学院妇产科系,副教授,实验室主任
2009- 美国霍夫斯特拉大学医学院,副教授,实验室主任
2011- 美国德州西南医学院和康奈尔大学医学院,临床教授,实验室主任


获奖及荣誉
1985-1993 曾获国家成果奖一项, 国家星火奖一项,省部级科技进步二等奖七项,三等奖九项,四等奖十项,以及其它奖项,共计三十余项国内外科技奖励
1992 当选为青年科学家(文库著者),中国科协 (见1993年光明日 报)
2011 两项美国专利, SperMagic® 精子伟哥和 iVitri® 玻璃化冷冻管
1994                  米兰研究奖,美国米兰基金会
1998                  青年科学奖,美国男性生殖和泌尿学会
2005                  被 IBC of Cambridge 推选为世界杰出科学家
2006                  被美国病理学会 评为杰出检查员

名誉学衔
2002-现在 北京大学客座教授、山东大学流动教授、吉林大学兼职教授、郑州大学客座教授、 内蒙古大学客座教授、安徽医科大学客座教授、广州中医药大学特聘教授、新疆医科大学客座教授,山东省立医院名誉教授; 中山医科大学第六医院顾问专家


主要研究方向
配子发生、卵子成熟和老化、精子功能和受精生物学
早期胚胎发育及调控
干细胞的功能及分化
遗传学、表观遗传学及印记基因
辅助生殖技术及其安全性

主要代表作

A.  主要代表著作
李媛,冯怀亮,陈子江 编著,《人类辅助生殖实验技术》,科学出版社,北京, 2008
冯怀亮著,《哺乳动物胚胎工程》,吉林科技出版社,1994。由中国科学院院士谈家桢教授作序,中国科学院、中国工程院院士王大珩教授寄语。系为青年科学家文库 ,又为当时非常有影响力的生物工程丛书之一 (见 1993 年 光明日 报)

B.  主要代表性论文(200 余篇)
Qiao J, Wang ZB, Feng HL, Miao YL, Wang Q, Yu Y, Wei YC, Yan J, Wang WH, Shen W, Sun SC, Schatten H,
Sun QY.  The root of reduced fertility in aged women and possible therapentic options: Current status and future
perspects, Mol Aspects Med. 2013 Jun 21. [Epub ahead of print]
Wang XM, Zhang Z, Tsai T, Feng HL. (2013) Impact of Gonadotrophins on Oocyte Maturation, Fertilization and
Developmental Competence in vitro: Animal Model. Reprod Fertil Dev. 2013 Jun 3. [Epub ahead of print]
Liu N, Ma Y, Li R, Jin H, Li M, Huang X, Feng HL, Qiao J. (2012) Comparison of follicular fluid amphiregulin and EGF concentrations in patients undergoing IVF with different stimulation protocols. Endocrine. 2012 Dec; 42(3):708-16.
Wang XM, Feng, H. L. (2012) How to Achieve the best ART pregnancy rate via sperm selection. J. Int. Reprod Health. 31:373-377
Hu WH, Mechesi D, Qiao J, Feng HL. (2012) Effect of slow freeze verus vitrification on the oocyte: An animal model. Fert. Steril. 98:752–60.
Marchesi D., Feng, H.L., Qiao.J. (2012) Embryo Manipulation and Imprinting, Seminars in Reprod Medicine,
30:323-334.
Liu S, Feng, HL.  (2011) Effect of gonadotropins on dynamic events and global DNA methylation during in vitro maturation
of oocytes: an animal model, Fertil Steril. 95(4):1503-1506.e3. Epub 2010 Nov 10.
Qiao J., Feng, H.L. (2011)Extra- and Intra-ovarian Factors in Polycystic Ovary Syndrome (PCOS): Impact on Oocyte Maturation and Embryo Developmental Competence. Human Reproduction Update, 17 (1): 17-33.
Liu S, Li Y, Feng HL, Yan JH, Chen ZJ (2010) Dynamic Modulation of Cytoskeleton During In Vitro Maturation in Human
Oocytes. Am J Obstet Gynecol. 203:151.e1-7.
Marchesi D, Biederman H, Hershlag A, Feng HL (2010) Effect of semen processing on sperm DNA integrity: Comparison of two techniques using a novel Toluidine Blue assay. European Journal of Obstetrics & Gynecology
And Reproductive Biology 151 (2010) 176–180
Sha W, Xu BZ. Li M, Liu D, Feng HL*, Sun QY.  (2010) Impact of Gonadotrophins on Oocyte Maturation in vitro: An Animal Model. Fertility and Sterility, 93:1650-61.
Feng H L. (2009) Spermatozoa defect and Fertilization Failure. J Reprod. Med. 18(3):187-189.
Han YB, Feng HL, Sandlow, J, Haines C. (2009) Comparing expression of progesterone and estrogen receptors in testicular tissue from men with obstructive and non-obstructive azoospermia, J. Andrology., 30:127-133.
Feng HL. Han YB, Sparks AET, Sandlow JI (2008) Characterization of Human Sperm Antigens Reacting with
Antisperm Antibodies from an Infertile Female Patient’s Serum. J Androl. 2008 Mar 20;29:440–448
Feng HL, Hershlag A, Scholl GM, Cohen M. (2009) A retroprospective study comparing four different assisted hatching techniques. Fertility and Sterility, 91:1323-5.
Marchesi DE, Feng HL (2007) Current assessment of sperm DNA integrity, Archives of Andrology,
53:239-247.
Marchesi D.E and Feng , HL. (2007) Sperm DNA Integrity from Sperm to Egg, Journal of Andrology, 28(4):481-489. Feng, H.L., Han, Y.B., Hershlag, A, Zheng, LJ. (2007) The Impact of Ca2+  Flux Inhibitors on Acrosome Reaction of
Hamster Spermatozoa, J. Andrology, 28(4):561-4.
Feng, H.L., Hershlag, A., Han, Y.B., Zheng, L.J. (2006) Localizations of intracellular calcium and Ca2+-ATPase in hamster spermatogenic cells and spermatozoa, Microscope Res. Tech. 69:618-623.
Feng, HL. Han, Y.B., Hershalg, A., Yang, H. (2006) New Hope for Infertility Therapy: Fabricating Gametes from
StemCells, Arcives of Andrology., 52:233-8.
Chen, Z.J., Yuan, J.H., Feng, H.L. (2005) Source of the extra pronucleus after intracytoplasmic sperm injection?
Fertility and Sterility,  84(5):1553-1554.
Herhlag A., Feng, H.L. (2005) Impact of medium pH on murine embryogeneis,  Fertility 4:21-22.
Li, Y., Feng, H.L., Cao, Y.J., Ma, S.Y., Li, M., Hu, J.M., Chen, Z.J. (2006) Confocal Microscopy Analysis of the
Spindle and Chromosome Configurations of Human Oocytes Matured in vitro. Fertility and Sterility, 85(4):827-
32.
Hershlag, A., Feng, H.L. (2005) The Effect of Pre-Freeze Assisted Hatching on Post-Thaw survival of mouse embryos, Fertility and Sterility,  84(6):1752-1754.
Chen, Z. J., Yan, J.H., Feng, H.L. (2005) Aneuploid Analysis of tripronuclear zygotes derived from in-vitro
fertilization and intracytoplasmic sperm injection in human, Fertility and Sterility, 83:1845-8.
Feng, H.L., Sandlow, J.I., Zheng, L.J. (2004) The c-kit receptor and its possible function in human spermatozoa,
Molecular Reproduction and Development, 70:103-110.
Chen, Z. J., Li, M.,  Li, Y., Feng, H.L. (2004) Effects of Sucrose Concentration on the Developmental Potential of
Human Frozen-Thawed Oocytes at Different Maturity Stages, Human Reproduction, 19(10 ):2345–2349.
Xu, H.P., H.L. Feng (2004) Localization and expression of the TSP50 protein in human and rodent testis, Urology,
64 (4):826-832
Feng, H.L., Hershlag, A. (2003) Fertilization abnormalities following human in-vitro fertilization and
intracytoplasmic sperm injection,  Microsc Res Tech., 61(4):358-61.
Hershlag, A., Feng, H. L. (2003) Betadine (povidone-iodine) is toxic to murine embryogeneis , Fertility and Sterility, 79(5):1249-1250.
Feng, H. L. (2003) Molecular Biology of Male Infertility, Archives of Andrology, 49:19-27.
Hershlag, A., Pain, T, Kvapil, G., Feng, H.L. (2002) In vitro fertilization-intracytoplasmic sperm injection split: an insemination methos to prevent fertilization failure, Fertil. Steril. 77:229-32.
Feng, H.L., Sandlow, JI., Sparks, AET. (2001) Decreased expression of the heat shock protein hsp70-2 is associated
with the pathogenesis of male infertility, Fert. Steril. 76:1136-1139.
Feng, H.L., Sandlow, JI., Sparks, AET., Sandra, A., Zheng, LJ. (1999) Decreased expression of the c-kit  receptor
is associated with increased apoptosis in subfertile human testes, Fertil. Steril. 71:85-89.
Feng, H.L., Sandlow, JI., Sandra, A., Sparks, AET. (1999) Development of Immunocontraceptive vaccine:
current status, J. Reprod. Medicine. 44:759-765.
Feng, H.L., Sandlow, J.I. and Sandra, A. (1998) Presence of c-kit receptor and its possible signaling
pathway in mouse sperm, Mol. Reprod. Dev. 49:317-326.
Sandlow, J.I., Feng, H.L. Zheng, L.J.and Sandra, A. (1999) Migration and localization of the c-kit receptor protein in
spermatogenetic cells and spermatozoa of the mouse, J. Urology, 161:1676-80.
Sandlow, J.I., Feng, H.L. and Sandra, A. (1997) Localization and expression of the c- kit receptor protein
in human and rodent testis and spermatozoa, Urology., 49:494-500.
Feng, H.L., Sandlow, J.I. and Sandra, A (1997) Expression and function of the c-kit proto-oncogene
protein in mouse sperm, Biol. Reprod.57: 194-203.
Feng, H.L., Wen, X.H., Theodore, A., and Presser, S.C. (1996) Effect of different coculture systems in
early human embryo development, Human Reproduction., 11:1525-1528.
Sandlow, J.I., Feng, H.L. and Sandra, A. (1996) Expression of c-kit and its ligand, stem cell factor, in
normal and subfertile human testicular tissue, J. Andrology,  17:403-408.
Sun Q.Y.  Yang Q.Z. Liu G.Y. Feng H.L (1995) Cryopreservation of bovine oocytes matured in vitro, Theriogenology, 43:329-330.
Feng, H.L., Yang, Q.Z., Sun, Q.Y., Qin, P.C. and Liu, J.M. (1994) Development of early bovine embryos in different culture systems, Vet. Rec., 135:304-306.
Feng, H.L., Liu, J.M., Wen, X.H., Wang, J., Sun, Q.Y. and Qin. P.C. (1994) Follicular oocyte maturation
and sperm penetration in vitro in the silver fox (vulpes vulpes),  Anim. Reprod. Sci., 36:163-170.
Feng, H.L. and Sun, Q.Y. (1995) Cryopreservation of bovine oocytes matured in vitro, J. Anim.
Sci. Vet. Med., 26:481-486.
Feng, H.L. and Sun, Q.Y. (1994) Development competence of bovine follicular oocytes after cryopreservation,  J. Vet. Sci.,
14:341-345.



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