教育经历
理学博士,美国加州大学圣地亚哥分校,1990,化学
理学学士,北京大学,1984,化学
工作经历
2010-现在,北京大学生物动态光学成像中心主任
2010-现在,北京大学化学与分子工程学院,兼职教授
2009-现在,北京大学生命科学学院长江讲座教授,
2009-现在,哈佛大学化学与化学生物学,Mallinchrodt讲席教授
1999-2008,哈佛大学化学与化学生物学,化学教授
1992-1998,美国太平洋西北国家实验室(NPPL),环境分子科学实验室,Senior Research Scientist to Chief Scientist
1990-1992,美国芝加哥大学Graham R. Fleming组,博士后
主要研究方向
单分子光谱学、单分子酶学、分子相互作用、构象动态学及大分子的作用机理、活细胞的基因表达、非线性光学成像技术及其生命科学与医学应用。
获奖及荣誉
2013,美国光学学会及应用光谱学会Ellis R. Lippincott奖
2012,美国化学会Rochester分部Harrison Howe奖
2012,美国微生物学会会士
2012,美国生物物理学会Founders奖
2011,美国科学院院士
2010,中国化学会荣誉会士
2009,美国能源部劳伦斯奖,化学类
2008,美国物理学会会士
2008,Berthold Leibinger Zukunftspreis激光奖
2007,Willis E.Lamb激光科学与量子光学奖
2006,美国科学促进会(AAAS)会士
2006,美国生物物理学会会士
2004,美国NIH Director’s Pioneer Award
2003,以色列Raymond and Beverly Sackler 物理科学奖
2003,哈佛大学Hoope奖获得者,Joe Markson优秀本科毕业论文指导教师
1996,Coblentz协会,Coblentz奖
主要代表性论文
20,Sangjin Kim &, Erik Broströmer&, Dong Xing&, Jianshi Jin&, Shasha Chong, HaoGe, Siyuan Wang, Chan Gu, Lijiang Yang, Yi Qin Gao, Xiao-dong Su*, Yujie Sun*, X. SunneyXie*, Probing Allostery Through DNA. Science 2013, 339:816-819 (2013)
19,Zong, Chenghang; Lu, Sijia; Chapman, Alec R.; Xie, X. Sunney. "Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell," Science 338, 1622-1626 (2012).
18, Lu, Sijia; Zong, Chenghang; Fan, Wei; Yang, Mingyu; Li, Jinsen; Chapman, Alec R.; Zhu, Ping; Hu, Xuesong; Xu, Liya; Bai, Fan; Qiao, Jie; Tang, Fuchou; Li, Ruiqiang; Xie, X. Sunney. "Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing," Science 338, 1627-1630 (2012).
17, Taniguchi, Yuichi; Choi, Paul J.; Li, Gene-Wei; Chen, Huiyi; Babu, Mohan; Hearn, Jeremy; Emili, Andrew; Xie, X. Sunney "Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells" Science, 329, 533-538 (2010).
16, Min, Wei; Lu, Sijia; Chong, Shasha; Roy, Rahul; Holtom, Gary R.; Xie, X. Sunney "Imaging chromophores with undetectable fluorescence by stimulated emission microscopy" Nature, 461, 1105-1109 (2009).
15, Blainey, Paul C.; Luo, Guobin; Ko9u, S.C.; Mangel, Walter F.; Verdine, Gregory L.; Bagchi, Biman; Xie, X. Sunney "Nonspecifically bound proteins spin while diffusing along DNA" Nature Structural & Molecular Biology, 16, 1224-1229 (2009)
14, Freudiger, Christian W.; Min, Wei; Saar, Brian G.; Lu, Sijia; Holtom, Gary R.; He, Chengwei, Tsai, Jason C.; Kang, Jing X.; Xie, X. Sunney "Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy," Science, 322, 1857-1861 (2008)
13, Choi, Paul J.; Cai, Long; Frieda, Kirsten; Xie, X. Sunney "A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell," Science, 322, 442-446 (2008).
12, Elf, Johan; Li, Gene-Wei; Xie, X. Sunney "Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell," Science, 316, 1191-1194 (2007).
11, Kim, Sangjin; Blainey, Paul C; Schroeder, Charles M; Xie, X. Sunney "Multiplexed single-molecule assay for enzymatic activity on flow-stretched DNA," Nature Methods, 4, 397-399 (2007).
10, Lee, Jong-Bong; Hite, Richard K.; Hamdan, Samir M.; Xie, X. Sunney; Richardson, Charles C.; van Oijen, Antoine M. "DNA primase acts as a molecular brake in DNA replication," Nature, 439, 621-624 (2006).
9, Xie, X. Sunney; Yu, Ji; Yang, Wei Yuan "Living Cells as Test Tubes," Science, 312, 228-230 (2006).
8, Yu, Ji; Xiao, Jie; Ren, Xiaojia; Lao, Kaiqin; Xie, X. Sunney; "Probing Gene Expression in Live Cells, One Protein Molecule at a Time," Science, 311, 1600-1603 (2006).
7, Cai, Long; Friedman, Nir; Xie, X. Sunney "Stochastic protein expression in individual cells at the single molecule level," Nature, 440, 358-362 (2006).
6, English, Brian P.; Min, Wei; van Oijen, Antoine M.; Lee, Kang Taek; Luo, Guobin; Sun, Hongye; Cherayil, Binny J.; Kou, S.C.; Xie, X. Sunney "Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited," Nat. Chem. Bio., 2, 87 (2006).
5, Yang, Haw; Luo, Guobin; Karnchanaphanurach, Pallop; Louie, Tai-Man; Rech, Ivan; Cova, Sergio; Xun, Luying; Xie, X. Sunney "Protein conformational dynamics probed by single-molecule electron transfer," Science 302, 262 (2003).
4, van Oijen, Atoine M. ; Blainey, Paul C. ; Crampton, Donald J. ; Richardson, Charles C. ; Ellenberger, Tom; Xie, X. Sunney "Single-Molecule Kinetics of l Exonuclease Reveal Base Dependence and Dynamic Disorder," Science 301, 1235 (2003).
3, Lu, H. Peter, Xun, Luying; Xie, X. Sunney "Single Molecule Enzymatic Dynamics," Science 282, 1877 (1998).
2, Lu, H. Peter; Xie, X. Sunney "Single-Molecule Spectral Fluctuations at Room Temperature," Nature 385, 143 (1997).
1, Xie, X. Sunney; Dunn, Robert C. "Probing Single Molecule Dynamics," Science 265, 361 (1994).
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