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Xu Zhi

智 旭
副研究员

研究方向:
蛋白质翻译后修饰与胚胎发育

受教育经历
2004/04-2008/03,(日本)大阪市立大学医学院,妇产科,博士
2002/09-2004/02,首都医科大学北京妇产医院,妇产科,硕士中退出国
1994/09-1999/07,中国医科大学,临床医学,学士
研究工作经历
2013/10 -至今,   北京大学,第三医院,生殖医学中心,副研究员
2011/12-2013/09,(美国)中佛罗里达大学医学院,助理研究员
2008/10-2011/12,(美国)奥尔巴尼医学院,博士后
2008/04-2008/09,(日本)大阪市立大学医学院,妇产科,研究助手
1999/08 -2002/08,北京第二炮兵总医院,妇产科,临床医师

期刊论文
1.Menon V, Zhi X, Masternak MM*. The contribution of visceral fat to improved insulin signaling in Ames dwarf mice. Aging Cell.[SCI收录;影响因子: 5.7]
2.List EO, Berryman DE, Funk K, Jara A, Kelder B, Wang F, Stout MB, Zhi X, Sun L, White TA, Lebrasseur NK, Pirtskhalava T, Tchkonia T, Jensen EA, Zhang W, Masternak MM, Kirkland JL, Miller RA, Bartke A, Kopchick JJ*. Liver-specific GH receptor gene disrupted (LiGHRKO) mice have decreased endocrine IGF-1, increased local IGF-1 as well as altered body size, body composition and adipokine profiles. Endocrinology. 2014 Feb 11:en20132086. [Epub ahead of print] [SCI收录,影响因子:4.5]http://www.ncbi.nlm.nih.gov/pubmed/24517230
3.Zhi X, Zhao D, Wang Z, Zhou Z, Wang C, Chen W, Liu R*, Chen C*. E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation. Cancer Research. 1;73(1):385-94. 2013. [SCI收录,影响因子: 8.2]
4.Zhi X, Zhao D, Zhou Z, Liu R, Chen C*. YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor. The American Journal of Pathology. 180(6):2452-61. 2012.[SCI收录,影响因子: 5.6]
5.Zhi X, Chen C*. WWP1: a versatile E3 ubiquitin ligase in signaling and diseases. Cellular and molecular life sciences : CMLS. 69(9):1425-34. 2012.[SCI收录,影响因子: 6.5]
6.Zhao D, Zhi X(并列第一作者), Zhou Z, Chen C*. TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis. Carcinogenesis. 33(1):59-67. 2012.[SCI收录,影响因子: 5.2]
7.Wang X, Hu G, Gao X, Wang Y, Zhang W, Harmon EY, Zhi X, Xu Z, Lennartz MR, Barroso M, Trebak M, Chen C, Zhou J*. The Induction of Yes-Associated Protein Expression After Arterial Injury Is Crucial for Smooth Muscle Phenotypic Modulation and Neointima Formation. Arteriosclerosis, thrombosis, and vascular biology. 32(11):2662-9. 2012.[SCI收录,影响因子: 7.0]
8.Honda K, Kajitani K*, Nobeyama K, Kira Y, Yabunaka Y, Egami M, Zhi X, Fukuda T, Yoshida Y, Matsumoto Y, Ichimura Y, Yaui T, Sumi T, Ishiko O. An Upstream Estrogen Response Element Linked to Exogenous p53 Tumor Suppressor Gene Expression Differentiates Effects of the Codon 72 Polymorphism. Asian Pacific Journal of Cancer Prevention : APJCP. 12(4):865-8. 2011.[SCI收录,影响因子: 0.7]
9.Yoshida H*, Sumi T, Zhi X, Yasui T, Honda K, and Ishiko O. Claudin-4: a potential therapeutic target in chemotherapy-resistant ovarian cancer. Anticancer Research. 31(4):1271-7. 2011.[SCI收录,影响因子: 1.6]
10.Zhi X*, Honda K, Sumi T, Yasui T, Nobeyama H, Yoshida H, Ishiko O. Estradiol-17β regulates vascular endothelial growth factor and Bcl-2 expression in HHUA cells. International Journal of Oncology. 31(6):1333-8. 2007.[SCI收录,影响因子: 2.6]
11.Zhi X, Honda K*, Ozaki K, Misugi T, Sumi T, Ishiko O. Dandelion T-1 extract up-regulates reproductive hormone receptor expression in mice. International Journal of Molecular Medicine. 20(3):287-92. 2007.[SCI收录,影响因子: 2.2]
12.Noriyuki M, Sumi T*, Zhi X, Misugi F, Nobeyama H, Yoshida H, Matsumoto Y, Yasui T, Honda K, and Ishiko O. Vascular endothelial growth factor, matrix metalloproteinases, and cyclooxygenase-2 influence prognosis of uterine cervical cancer in young women. International Journal of Oncology. 31(3):531-6. 2007.[SCI收录,影响因子: 2.6]

会议发表
1.Zhi X, Zhao D, Zhou Z, Chen C. RNF126 E3 ubiquitin ligase targets p21cip for ubiquitin-mediated degradation. American Association for Cancer Research (AACR) 103rd Annual Meeting. 2011. Orlando FL USA. 2012. Chicago IL USA.
2.Zhi X, Zhao D, Zhou Z, Chen C. RNF126 E3 ubiquitin ligase targets p21cip for ubiquitin-mediated degradation. Keystone Symposia on Molecular and Cellular Biology. 2012. Whistler, BC Canada.
3.Zhi X, Zhao D, Chen C. RNF126, a novel E3 ubiquitin ligase, promotes cancer cell proliferation through targeting p21 for ubiquitin-mediated degradation. 5th Translational Oncology Research Symposium. 2011. Albany NY USA.
4.Zhi X, Zhao D, Zhou Z, Liu R, Chen C. YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor. American Association for Cancer Research (AACR) 102nd Annual Meeting. 2011. Orlando FL USA.
5.Zhao D, Zhi X, Zhou Z, Liu R, Chen C. TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation. American Association for Cancer Research (AACR) 102nd Annual Meeting. 2011. Orlando FL USA.
6.Zhao D, Zhi X, Chen C. KLF5 and TAZ coordinately promote breast cancer proliferation and survival. 4th Translational Oncology Research Symposium. 2010. Albany NY USA.
7.Honda K, Zhi X, Sumi H, Ishiko O. Estradiol-17β regulates the expression of angiogeneis-related factors in endometrial cancer, and the possible relation with characteristic estrogen receptor expression pattern. 60nd Annual Congress of the Japan society of Obstetrics and Gynecology. 2008. Yokohama, Japan.
8.Honda K, Zhi X, Ishiko O. The therapeutic effects of Kihitou on endometrial carcer in regulating p53 expression. 57th Anuual Congress of the Japan society for oriental medicine. 2006. Osaka, Japan.

获奖情况

获奖时间  内容
2007年    中国国家优秀自费留学生-该奖项为中华人民共和国国家级奖项,并于2008年4月在中华人民共和国驻日本国大使馆受到当时驻日大使崔天凯-现任驻美国大使-的亲自接见与表彰,并合影留念。

2006/04 -2008/03    日本ROTARY YONEYAMA优秀博士生奖学金